CASE REPORT OF SUCCESSFUL TREATMENT OF ACUTE SUPERWARFARIN RODENTICIDES POISONING IN DEPARTMENT OF OCCUPATIONAL DISEASES, MILITARY HOSPITAL 175

Thị Trúc Quỳnh Vũ1, , Đức Thiện Cao1, Vinh Quang Bùi1
1 Bệnh viện Quân y 175

Main Article Content

Abstract

In recent years, the Department of Occupational Diseases, Military Hospital 175 has treated many emergency cases of patients with new generation rat poison poisoning. The old-generation rat poisons which existed 10-20 years ago causing convulsions, coma, and cardiac arrhythmias. Therefore, they have been banned and rarely re-appeared. Followed by the very popular superwarfarin rodenticides poisoning.

We report a case of a 53 years old man who drank 2 ampoules of supperwarfarin and referred to Military Hospital 175 after 4 weeks. The patient was admitted to the hospital with bleeding accompanied by severe coagulopathy, he was actively treated with fresh frozen plasma and blood transfusion, vitamin K1, hemostasis drug. After 7 days, the patient’s health was improved.

Article Details

References

Bộ Y Tế (2015), Hướng dẫn chẩn đoán và xử trí ngộ độc, Hà Nội, 74- 79.
Lo VM, Ching CK, Chan AY, Mak TW (2008). Bromadiolone toxicokinetics: diagnosis and treatment implications. Clin Toxicol (Phila); 46:703– 10.
Spahr JE, Maul JS, Rodgers GM (2007). Superwarfarin poisoning: a report of two cases and review of the literature. Am J Hematol; 82:656–60.
Bruno GR, Howland MA, McMeeking A, Hoffman RS (2000). Long-acting anticoagulant overdose: brodifacoum kinetics and optimal vitamin K dosing. Ann Emerg Med; 36:262–7.
King N, Tran M-H (2015). Long-Acting Anticoagulant Rodenticide (Superwarfarin) Poisoning: A Review of Its Historical Development, Epidemiology, and Clinical Management. Transfus Med Rev; 29:250–8.
Wu Y-F, Chang C-S, Chung C-Y, Lin H-Y, Wang C-C, Shen M-C (2009). Superwarfarin intoxication: hematuria is a major clinical manifestation. Int J Hematol; 90:170–3.
h t t p s : / / m o h . g o v . v n / h o m e ? p _ p _ i d = 1 0 1 & p _ p _ lifecycle=0&p_p_ state=maximized&p_p_ m o d e = v i e w & _ 1 0 1 _ s t r u t s _ action=%2Fasset_publisher%2Fview_ content&_101_type=content&_101_ urlTitle=canh-bao-ngo-oc-thuoc-diet-chuot-the-he-moi
Vandenbroucke V, Bousquet- Melou A, De Backer P, Croubels S (2008). Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration. J Vet Pharmacol Ther; 31:437–45.
Kelkar AH, Smith NA, Martial A, Moole H, Tarantino MD, Roberts JC (2018). An outbreak of synthetic cannabinoid–associated coagulopathy in Illinois. N Engl J Med; 379:1216–23.
aChua JD, Friedenberg WR. Superwarfarin poisoning (1998). Arch Intern Med; 158:1929–32.
David John C, Sebastian F, Krutica D (2014). Superwarfarin poisoning and its management, 74-80.