EVALUATION OF HYPERCALCEMIA DISORDER AMONG OLDER ADULTS WITH CANCER

Ngọc Hoành Mỹ Tiên Nguyễn1, , Lý Mỹ Châu Trần2, Hà Ngọc Thể Thân1
1 Đại học Y dược TP. HCM, BV Đại học Y dược TP. HCM
2 Bệnh viện Chợ Rẫy

Main Article Content

Abstract

Objectives: To evaluate the state of hypercalcemia in the older adults with cancer at the Department of Palliative Treatment, Cho Ray Hospital.

Methods: A cross-sectional, descriptive, prospective study was conducted on 46 older patients (≥ 60 years old) with cancer, at the Department of Palliative Medicine, Cho Ray Hospital from 11/2020 to 06/2021, with elevated of corrected total blood calcium concentration (>2.6 mmol/L).

Results: The prevalence of hypercalcemia in older adults with cancer was 2%, with lung tumors accounting for 17.4%, bone and liver metastases accounting for 37%. The infection rate was up to 60.9%. Most patients had impaired kidney function, glomerular filtration rate from 15 to less than 60 milliliters per minute accounted for 34.8%, glomerular filtration rate decreased significantly < 15, accounting for 58.7%. Severe progression accounted for 45.7%, mortality rate was 6.5%.

Conclusions: The prevalence of hypercalcemia in older adults with cancer was 2%, with diverse clinical features. Most of them have severe renal failure, severe clinical progression, mortality rate was 6.5%.

Article Details

References

Nam UV, Duc NM. Già hóa dân số và người cao tuổi ởViệt Nam.
Grill V, Martin TJ. Hypercalcemia of malignancy. Reviews in Endocrine and Metabolic Disorders. 2000 Nov;1(4):253-263.
Stewart AF. Hypercalcemia associated with cancer. New England Journal of Medicine. 2005 Jan 27;352(4):373-379.
Chan JY, Kanthaya M. Hypercalcaemic crisis in an elderly patient with pulmonary tuberculosis. Oxford Medical Case Reports. 2015 Nov 1;2015(11):354-357.
Extermann M, Hurria A. Comprehensive geriatric assessment for older patients with cancer. Journal of Clinical Oncology. 2007 May 10;25(14):1824-1831.
Lindner G, Felber R, Schwarz C, et al. Hypercalcemia in the ED: prevalence, etiology, and outcome. The American journal of emergency medicine. 2013 Apr 1;31(4):657-660.
Kuchay MS, Kaur P, Mishra SK, et al. The changing profile of hypercalcemia in a tertiary care setting in North India: an 18-month retrospective study. Clinical Cases in Mineral and Bone Metabolism. 2017 May;14(2):131.
Catalano A, Chilà D, Bellone F, et al. Incidence of hypocalcemia and hypercalcemia in hospitalized patients: Is it changing? Journal of clinical & translational endocrinology. 2018 Sep 1;13:9-13.
Bhandari S, Kumar R, Tripathi P, et al. Outcomes of hypercalcemia of malignancy in patients with solid cancer: a national inpatient analysis. Medical Oncology. 2019 Oct;36(10):1-6.
Penel N, Dewas S, Doutrelant P, et al. Cancer-associated hypercalcemia treated with intravenous diphosphonates: a survival and prognostic factor analysis. Supportive Care in Cancer. 2008 Apr;16(4):387-392.