ASSOCIATION BETWEEN HYPOPHOSPHATEMIA WITH WEANING FAILURE IN MECHANICALLY VENTILATION PATIENTS
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Abstract
Background: The hypophosphatemia have been reported associated with weaning. However, the level of evidence is not strong enough. This study was performed which objective of study was to determine the association between the hypophosphatemia with weaning failure in invasive mechanical ventilation patients.
Methods: A prospective cohort with 94 weaning trials, which had enough the standards of weaning. There were included and exclusion criteria. The primary outcome was the weaning failure (yes/no). The control confounding variables were age group ≥ 65, malnutrition, COPD, heart failure, brain damage, and lung injury.
Results: The hypophosphatemia ≤ 0.8 mmol /l were 36 weaning trials (38.3%). The weaning failure was 32 weaning trials (34%). The weaning failure of the hypophosphatemia patients was (20 weaning trials, 55.6%), higher than the normal phosphatemia patients (12 weaning trials, 20.7%). Stratified analysis, the control variable is not interactive elements, and confounders. Compared with normal phosphatemia, the hypophosphatemia increases the risk of weaning failure with RR = 2.69, 95% confidence interval from 1.5 to 4.81, p <0.01.
Conclusion: through this study, the results showed hypophosphatemia increased 3 times the risk of weaning failure, prolonged duration of mechanical ventilation. Therefore, the blood phosphorus should be interested in tracking and adjusted in blood phosphorus decreased, blood phosphorus decreased especially in mechanically ventilated patients.
Keywords
phosphatemia, phosphorus, hypophosphatemia, weaning ventilator, weaning ventilation failure, , risk factors of weaning ventilation failure
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References
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